Sonablate hifu prostate clinical trial us

Download Brochure. Sonablate HIFU. Where is the procedure available? Most medical treatments, including HIFU, are performed in brief time frame. In fact, diagnosis, arriving at a treatment decision and post-treatment care consumes the majority of patient-doctor time and care. Would it be okay if I fax the forms and their letter to you so you could complete the required information? Yes it is ok to fax.

But keep in mind that the only insurance quote we have is a non-specific code. The government has not provided an insurance CPT code. This was clearly stated on your initial patient information package. Rafael can provide a copy of this document if needed. When you have completed the form would you please send it on to BCBS?

We will be happy to do so. They accept this on an individual basis. He is finding that he is needing to urinate during the night several times disrupting his sleep. Life expectancy is another crucial point when deciding if a patient is eligible for salvage Hifu. As argued by Patekh A et al, men being considered for eligibility should have a long enough life expectancy to gain a reasonable chance to benefit from treatment If life expectancy is less than 5 years, the burden of side effects is too high to make salvage Hifu appropriate as a treatment option, as there is a high probability that this technique would reduce the quality of life without carrying a significant advantage in terms of overall survival.

In few words, life expectancy and side effects are two plates of a balance, and both should be weighed carefully for a cautious decision. This systematic review has some possible limitations. First of all, our analysis is made predominantly on retrospective studies. In addition, many studies we went through are of poor quality, which reduces the number of studies that were considered.

Another weak point is the heterogeneity of data collected, that made it difficult to compare the results. The criteria for defining recurrence is not the same through the series considered, and the Stuttgart criterion, even if specific for Hifu, is the less used. We have already discussed about side effects reporting systems, that were very different among authors, thus making it challenging to come to a significant conclusion.

This certainly is another limitation of our analysis. In conclusion, from the data analyzed it can be stated that salvage Hifu may have potential as a treatment option in radiorecurrent prostate cancer and its effectiveness in cancer control is higher in selected groups of patients, as low- and intermediate-risk and in patients with a low pre-salvage PSA.

Supposing that it may be considered feasible by the ethical point of view, a randomized controlled trial comparing focal treatment modalities would add more value to the current data, as it would improve the approach to radiorecurrent prostate cancer, by selecting patients to be treated with the most appropriate technique. The advent of PSA and its derivatives, as well as the refinements in the radiologic techniques have increased the detection rate of prostate cancer, thus leading to a higher number of patients treated and a higher number of recurrent cancers.

Among these, High Intensity Focused Ultrasound Hifu may be used within a clinical trial setting or a well-designed prospective cohort study. Our systematic review aims to provide more insight on the oncologic outcome on salvage Hifu, in the context of the heterogeneity of the studies reported in the literature.

In conclusion, data collected across our review revealed that salvage Hifu is effective in the management of radiorecurrent clinically localized prostate cancer. Our study, however, highlighted the lack of robust data on this technique in a salvage setting and we may also conclude arguing that large, multicentric, well designed trials are advisable. Each author declares that he or she has no commercial associations e. National Center for Biotechnology Information , U.

Journal List Acta Biomed v. Acta Biomed. Published online Sep 2. Author information Article notes Copyright and License information Disclaimer.

Corresponding author. Received Mar 1; Accepted Mar This work is licensed under a Creative Commons Attribution 4. Abstract Introduction. Material and methods. Literature search and selection We reviewed the literature focusing on side effects and morbidity of HIFU treatment for prostate cancer with the following key words: hifu, salvage hifu, high intensity focused ultrasound, ultrasonic therapy, transrectal hifu, prostate ablation, focal hifu, radiorecurrent prostate cancer.

Open in a separate window. Figure 1. Results After literature search and selection see Figure 1 , demographic and preoperative data are reported in Table 1 , while data about the procedure and oncologic outcome, including follow-up, are reported in Table 2. Table 1. Table 2. Discussion After the advent of PSA, the refinements in the diagnostic technologies, including PSA derivatives and images technologies 33 , 34 , led to an increased number of patients diagnosed with and treated for prostate cancer.

Conclusion The advent of PSA and its derivatives, as well as the refinements in the radiologic techniques have increased the detection rate of prostate cancer, thus leading to a higher number of patients treated and a higher number of recurrent cancers. Conflicts of interest: Each author declares that he or she has no commercial associations e. External radiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: year results of an EORTC randomised study.

Lancet Oncol. Comparative evaluation of radiation treatments for clinically localized prostate cancer: an updated systematic review. Ann Intern Med.

Treatment failure after primary and salvage therapy for prostate cancer: likelihood, patterns of care, and outcomes. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomized, non-inferiority, phase 3 CHHiP trial.

Mid-term results demonstrate salvage High-intensity focused ultrasound HIFU asan effective and acceptably morbid salvage treatment option for locally radiorecurrent prostate cancer. Eur urol. Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases. J Clin Oncol. Salvage therapy options for local prostate cancer recurrence after primary radiotherapy: a literature review. Curr Urol Rep. Current salvage methods for recurrent prostate cancer after failure of primary radiotherapy.

BJU Int. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. The biological application of focused ultrasound waves. Ultrasonically produced localized selective lesions in the central nervous system. Am J Phys Med. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.

Federal Government. Read our disclaimer for details. Last Update Posted : September 28, Leonard S. Marks, M. Study Description. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through clinical data and health-related quality of life HRQOL questionnaires.

Detailed Description:. This observational study will serve to collect data from medical record review and questionnaires before and after High Intensity Focused Ultrasound HIFU for focal ablation of prostate tissue.

The subject will have already undergone or opted to receive the HIFU procedure as part of standard of care in order to participate in this study. MedlinePlus related topics: Prostate Cancer.